| Introduction |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Miscellaneous
“The Forum on Fundamental Surgical Problems was instituted by the Board of Regents of the American College of Surgeons to provide an opportunity to the younger surgical group, for the presentation of ...
|
|
S1
|
|
| Dedication |
| |
Article Title |
Author(s) |
Pages |
|
|
|
The 62nd Volume of the Surgical Forum Is Dedicated to Eric W Fonkalsrud, MD, FACS
Each year, the Committee for the Forum on Fundamental Surgical Problems selects a Fellow whose career has been extraordinarily distinguished, focused on the development of young surgeons, and devoted ...
|
O. Joe Hines
|
S2-S3
|
|
| Surgical Forum Dedications |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Surgical Forum Dedications
Past volumes of the Surgical Forum have been dedicated to the following Fellows of the College:
|
|
S4
|
|
| Surgical/Fellow Excellence in Research Awards |
| |
Article Title |
Author(s) |
Pages |
|
|
|
American College of Surgeons Owen H Wangensteen Forum on Fundamental Surgical Problems: Resident/Fellow Excellence in Research Awards 2011
For the ninth consecutive year the American College of Surgeons' Owen H Wangensteen Forum on Fundamental Surgical Problems presents Resident/Fellow Excellence in Research Awards. The major objectives ...
|
|
S5-S12
|
|
| Alimentary Tract I |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Evaluation of fibrin glue for biologic mesh placement at the hiatus in a porcine model
The ideal method to secure mesh during laparoscopic hiatal hernia repair remains uncertain. Suture or tack fixation can be technically difficult and serious vascular complications have been reported. ...
|
David M. Krpata,
Jeffrey A. Blatnik,
Karem C. Harth,
Melissa S. Phillips,
Yuri W. Novitsky,
Michael J. Rosen
et al.
|
S13
|
|
|
|
High resolution manometry patterns of lower esophageal sphincter complex in symptomatic post-fundoplication patients
There has been an increase in the number of patients seeking treatment after an anti-reflux surgical procedure. The objective of this study is to evaluate high-resolution manometry (HRM) lower esophag...
|
Masato Hoshino,
Abhishek Sundaram,
Arpad Juhasz,
Fumiaki Yano,
Kazuto Tsuboi,
Tommy H. Lee,
Sumeet K. Mittal
et al.
|
S13
|
|
|
|
Roux-en-Y gastric bypass improves female quality of life
Obesity is a risk factor for sexual dysfunction and urinary incontinence. We hypothesize an improvement in sexual function and pelvic floor function following Roux-en-Y Gastric Bypass (RYGB).
|
Shushmita Ahmed,
Jennifer Higa,
Kate Kiely,
Zaina Arslan,
John M. Morton
et al.
|
S13
|
|
|
|
Islet apoptosis inhibition secondary to glut4 overexpression in skeletal muscles of GK rats after Roux-en-Y gastric bypass surgery
This investigation was focused on the islet apoptosis inhibition and remission of skeletal insulin resistance after Roux-en-Y gastric bypass surgery (RYGB).
|
Yong Wang
|
S14
|
|
|
|
The neuropathic pain mediator Cathepsin S (CatS) promotes activation of nociceptive pathways in mouse pancreas
Peripheral nerve injury activates the cysteine protease CatS in spinal cord microglia, where it mediates and maintains neuropathic pain signaling. We demonstrated that CatS is markedly upregulated in ...
|
Victoria Lyo,
Austin Walker,
Tyson Kim,
Fiore Cattaruzza,
Matthew Bogyo,
Eileen Grady,
Nigel W. Bunnett,
Kimberly S. Kirkwood
et al.
|
S14
|
|
|
|
Interleukin 22: A novel mediator of inflammatory inhibition and tissue damage in acute pancreatitis
Acute pancreatitis (AP) remains a major clinical challenge with approximately 100,000 hospitalizations and 2,000 deaths per year in the U.S. This is partially due to the poorly understood mechanisms o...
|
Daniel F. Kim,
Albert Stanek,
Cathy M. Mueller,
Michael E. Zenilman,
Thomas K. Weber,
Antonio E. Alfonso,
Wenjun Ouyang,
Chongmin Huan
et al.
|
S14-S15
|
|
|
|
Corticotropin-releasing factor receptor 2 (CRF2) is essential for mediation of the urocortin1 anti-inflammatory response in experimental acute pancreatitis
Corticotropin Releasing Factor Receptors and their ligand Urocortin1 (Ucn1) are emerging as potent inflammatory mediators. We hypothesize that CRF2 actions are anti-inflammatory in experimental acute ...
|
Eric Kubat,
Eileen Grady,
Victoria Lyo,
Shilpi Mahajan,
Min Liao,
Kimberly S. Kirkwood,
Aditi Bhargava
et al.
|
S15
|
|
|
|
Advanced age is an independent risk factor for increased morbidity and mortality following open and laparoscopic cholecystectomy: A comparative analysis of 155,365 cholecystectomies from National Inpatient Sample (NIS) Database (2004-2008)
Cholecystectomy is the most common digestive surgery performed in the US and worldwide. Various factors influence selection of open versus laparoscopic cholecystectomy, however whether age alone is a ...
|
Robin Lee,
Sachin Patil,
Ronald Chamberlain
|
S15
|
|
|
|
The McGill-Brisbane score is an excellent predictor of survival in patients undergoing a pancreatico-duodenectomy for pancreatic adenocarcinoma
We have previously described and validated the McGill-Brisbane score (MBS), which predicts survival in palliative (unresectable) pancreatic adenocarcinoma patients. It is based on 4 clinical variables...
|
Mohammad Jamal,
Aboukhalil Jad,
Sinziana Dumitra,
Eve Simoneau,
Suhail Doi,
Jeffrey Barkun
et al.
|
S15-S16
|
|
|
|
Reduced postoperative recurrence and improved survival of pancreatic cancer with peritoneal dissemination by inhibition of nuclear factor-kappa B activation in mice
In spite of undergoing curative resection (R0) for the patients with pancreatic cancer, long-term survival is very poor because of high incidence of cancer recurrence. We previously reported that nafa...
|
Yuki Fujiwara,
Koichiro Haruki,
Kenei Furukawa,
Tomonori Iida,
Hiroaki Shiba,
Tadashi Uwagawa,
Takeyuki Misawa,
Toya Ohashi,
Katsuhiko Yanaga
et al.
|
S16
|
|
|
|
Pancreatic stellate cells activate chemokine receptor CCR9 signaling to promote pancreatic cancer cell invasion
We previously demonstrated that CCR9 activation by its ligand CCL25 increases pancreatic cancer cell proliferation. We hypothesized that tumor microenvironment cells may be a source for CCL25. Therefo...
|
Wendy Lee,
Xiaoming Shen,
Maithao N. Le,
Marjun P. Duldulao,
Jianming Lu,
Julio Garcia-Aguilar,
Joseph Kim
et al.
|
S16
|
|
|
|
Adipocytes cause enhanced migration of murine pancreatic cancer cells
Obesity is associated with increased incidence and accelerated progression of multiple malignancies, including pancreatic cancer. We have observed adipocytes within the tumor microenvironment of murin...
|
Patrick B. White,
Kathryn M. Ziegler,
Sue S. Wang,
Robert V. Considine,
Deborah A. Swartz-Basile,
Henry A. Pitt,
Nicholas J. Zyromski
et al.
|
S16-S17
|
|
| Alimentary Tract II |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Predictive factors of early bowel obstruction in colon and rectal surgery: Data from the Nationwide Inpatient Sample (NIS), 2006-2008
Early post-operative bowel obstruction is associated with significant morbidity and mortality following colorectal surgery. We evaluated patient characteristics, comorbidities, pathology, resection-ty...
|
Hossein Masoomi,
Steven Mills,
Joseph C. Carmichael,
Ninh T. Nguyen,
Michael J. Stamos
et al.
|
S18
|
|
|
|
The angiotensin II receptor blocker (ARB) losartan decreases post-operative intra-abdominal adhesions by modulating the renin-angiotensin system (RAS) and oxidative stress pathways
Post-operative intra-abdominal adhesions are a major source of morbidity and our understanding of their formation remains incomplete. Our laboratory has previously shown that reduced peritoneal fibrin...
|
Melanie L. Gainsbury,
Holly K. Sheldon,
Michael R. Cassidy,
Stanley Heydrick,
Somdutta Mitra,
Arthur F. Stucchi,
James M. Becker
et al.
|
S18
|
|
|
|
A Neurokinin-1 Receptor (NK1R) antagonist (NK-1RA) that reduces postoperative adhesions reduces the adhesion related chemokines CXCL1(KC) and CXCL2 (MIP-2) and their receptor, CXCR2
Postoperative adhesions occur in 90-100% of patients after abdominopelvic surgery. We previously showed that adhesiogenesis is associated with leukocyte migration into the peritoneum and that the NK1R...
|
Hisashi Kosaka,
Melanie Gainsbury,
Holly Sheldon,
Michael R. Cassidy,
Arthur Stucchi,
James M. Becker
et al.
|
S18-S19
|
|
|
|
Early enteral nutrients allows for discontinuation of peptide-2, intestinal adaptation and near complete independence from parenteral nutrition in a rat model of short bowel syndrome
Small bowel resection leading to short bowel syndrome (SBS) necessitates parenteral nutrition (PN). Glucagon-like peptide-2 (GLP-2) is a nutrient-dependent, proglucagon-derived gut hormone that stimul...
|
Adam S. Brinkman,
Patrick Solverson,
Sangita Murali,
Denise Ney
|
S19
|
|
|
|
Blockade of myeloid differentiation primary response gene 88 (myd88) pathway prevents total parenteral nutrition (TPN)-associated loss of epithelial barrier function (EBF) in a mouse model
Administration of TPN to mice leads to mucosal inflammation that decreases EBF and lowers glucose transport ability. Blockade of the myd88 signaling pathway can abrogate the pro-inflammatory response ...
|
Eiichi A. Miyasaka,
Daniel H. Teitelbaum
|
S19
|
|
|
|
S1P overexpression increases intestinal barrier protein expression
Intestinal barrier dysfunction is implicated in a wide variety of pathologic conditions such as sepsis and malignancy. Barrier integrity is highly dependent on tight and adherens junctions. Our lab ha...
|
Alexis D. Smith,
Ruiyun Li,
Ping Jiang,
Tontong Zou,
Lan Liu,
Lan Xiao,
Jian-Ying Wang,
James M. Donahue,
Douglas J. Turner
et al.
|
S19-S20
|
|
|
|
Hemin induction of HO-1 protects against LPS-induced sepsis and ileus
Heme oxygenase (HO-1) is known to protect against inflammation. This study demonstrated the protective function of hemin-induced HO-1 against LPS-induced ileus.
|
Marcus Overhaus,
Stephan Bortscher,
Johannes Chang,
Nico Schaefer,
Sven Wehner,
Joerg C. Kalff
et al.
|
S20
|
|
|
|
Downstream TLR-signaling contributes to inflammatory events within the postsurgical gut wall
Translocating commensal bacteria are sensed by means of Toll-like receptors (TLRs) within the gut wall. Consecutive microbial invasion can lead to substantial inflammatory molecular and cellular event...
|
Burkhard Stoffels,
Joerg C. Kalff,
Sven Wehner
|
S20
|
|
|
|
Anastomotic healing in the context of inhibited macrophage function and sepsis
Intestinal muscularis macrophages are initially involved in the surgically-induced local inflammatory response resulting in postoperative ileus. Inhibition of this specific macrophage function prevent...
|
Dimitrios Pantelis,
Anke Beissel,
Tim O. Vilz,
Sven Wehner,
Joerg C. Kalff
et al.
|
S20-S21
|
|
|
|
The postoperative ileus – an immunological disease?
Localized abdominal surgery frequently leads to postoperative ileus (POI). Intestinal macrophages are known to produce mediators paralyzing myocytes, but it is unclear how macrophages are activated, e...
|
Arne Koscielny,
D.R. Engel,
S. Wehner,
C. Kurts,
J.C. Kalff
et al.
|
S21
|
|
|
|
Organoid culture reproducibly expands intestinal crypts
Recent methodology to culture intestinal crypts into organoids has been described. We sought to establish reproducible culture methods that would markedly expand crypts, required for potential transla...
|
Megan K. Fuller,
Denver M. Faulk,
Susan J. Henning,
Michael A. Helmrath
|
S21-S22
|
|
|
|
Can synthetic mesh tolerate bacterial contamination? An experimental study
Modern synthetic meshes for ventral hernia repair are derived from various polymers, with unique filaments, pore sizes, and weights. Understanding how these properties might affect infectious complica...
|
Jeffrey A. Blatnik,
David M. Krpata,
Michael R. Jacobs,
Yuri W. Novitsky,
Michael J. Rosen
et al.
|
S22
|
|
| Alimentary Tract III |
| |
Article Title |
Author(s) |
Pages |
|
|
|
The impact of PICC Lines on Venous Thromboembolism (VTE) rates in patients who undergo bowel major bowel resection
VTE is an uncommon but morbid complication of bowel resections. The use of PICC lines has increased with broader indications. With current quality outcome measures, never events and costs the risks of...
|
Robert H.O. Nunoo,
Theodor Asgeirsson,
Heather Slay,
Sen Zhang,
Martin Luchtefeld
et al.
|
S23
|
|
|
|
Case selection during the learning curve in laparoscopic colorectal surgery – a multi-centre analysis of 4852 cases
The aim of this study was to analyse multi-centre learning curves and opinions of world-leading experts to recommend case selection in laparoscopic colorectal surgery.
|
Danilo Miskovic,
Melody Ni,
Susannah M. Wyles,
Paris Tekkis,
George B. Hanna
et al.
|
S23
|
|
|
|
Single institution monitoring of the implementation of laparoscopic resection of colon cancer
Multi-institutional trials demonstrate that laparoscopic colectomy (LC) for cancer is as safe as open colectomy (OC). It is important that individual centers track outcomes as more surgeons begin to p...
|
David A. Klima,
Victor B. Tsirline,
Igor Belyansky,
Amy E. Lincourt,
Kristian T. Dacey,
Kent W. Kercher,
B. Todd Heniford
et al.
|
S23-S24
|
|
|
|
Total mesorectal excision - does the choice of dissection technique have an impact on pelvic autonomic nerve preservation?
A variety of instruments for total mesorectal excision in rectal cancer patients has become available. The aim of this prospective experimental study was to compare the quality of pelvic autonomic ner...
|
Daniel W. Kauff,
Oliver Kempski,
Sabine Huppert,
Klaus P. Koch,
Klaus P. Hoffmann,
Hauke Lang,
Werner Kneist
et al.
|
S24
|
|
|
|
Radiologic measures of visceral adiposity and rectal cancer outcomes
The associations of body mass index (BMI) as a measure of obesity and cancer outcomes have been inconsistent. We sought to examine quantitative measures of visceral obesity and compare them to BMI in ...
|
C. Whalen Clark,
Colin M. Parsons,
Jonathan M. Hernandez,
Jill Weber,
Erin M. Siegel,
Shalini Thareja,
David Shibata
et al.
|
S24
|
|
|
|
Adenocarcinoma of the rectum in patients under age 40 is increasing: Impact of signet ring cell histology
Recent literature suggests an increased incidence of rectal cancer in patients under 40. Based upon our own practice pattern, we hypothesized that an increased incidence of rectal cancer in patients u...
|
Patrick S. Tawadros,
Ian M. Paquette,
Ann M. Hanly,
Anders F. Mellgren,
David A. Rothenberger,
Robert D. Madoff
et al.
|
S24-S25
|
|
|
|
Effects of intraluminal chemotherapy on colorectal cancer – study in an orthotopic murine model
Previously, intraluminal chemotherapy was used as an adjunct to surgery to decrease tumor micro metastasis. Theoretically, transanal chemotherapy offers benefits over conventional chemotherapy as it a...
|
Jasneet Singh Bhullar,
Amir Damadi,
Gokulakkrishna Subhas,
S.V.S. Malladi,
Jacqueline Tilak,
Navin Anthony,
Lee Andrus,
Milessa Decker,
Vijay K. Mittal
et al.
|
S25
|
|
|
|
Let-7 microRNA regulates p53 and K-ras in colorectal cancer cells
We observed that rectal cancers harboring mutant p53 and K-ras are resistant to chemoradiation therapy (CRT); yet a molecular link between p53 and K-ras remains unknown. Since let-7 microRNA (miRNA) m...
|
Marjun Philip Narciso Duldulao,
Wendy Lee,
Maithao Le,
Zhenbin Chen,
Wenyan Li,
Joseph Kim,
Julio Garcia-Aguilar
et al.
|
S25
|
|
|
|
Epithelial cell angiotensin II type 1a receptor (AT1aR) is critical in the pathogenesis of dextran sodium sulfate (DSS) acute colitis model
The renin–angiotensin system is expressed in the gastrointestinal mucosa, including epithelial cells (EC) and sub-epithelial lymphoid tissue; and increased abundance occurs in inflammatory processes. ...
|
Manabu Okawada,
Ryo Sueyoshi,
Daniel H. Teitelbaum
|
S25-S26
|
|
|
|
Gender is a determinant of the severity of experimental colitis
Epidemiological evidence suggests that men are at increased risk of developing colitis-associated colorectal cancer (CRC) compared to women. Because the severity of colitis correlates with the risk of...
|
Tomoki Makino,
David C. Montrose,
Kotha Subbaramaiah,
Jeffrey W. Milsom,
Andrew J. Dannenberg
et al.
|
S26
|
|
|
|
Prostaglandin D2 regulates human colonic transport in-vivo
Prostaglandins (PGs) are metabolites of arachidonic acid (AA) that exert a range of effects in different tissues and cells. The role of prostaglandins as intestinal ion transport modulators is well es...
|
Mekki Medani,
Helen Mohan,
Danielle Collins,
Alan W. Baird,
Des C. Winter
et al.
|
S26
|
|
| Biomarkers and Genetic Determinants of Disease and Outcomes |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Germline mutations in SMAD4 affect downstream BMP and TGF-Beta signaling
Juvenile Polyposis (JP) is an autosomal dominant disorder with a predisposition to GI cancer, and SMAD4 germline mutations account for 20% of cases. SMAD4 is essential to both the transforming growth ...
|
Fadi S. Dahdaleh,
Jennifer C. Carr,
Donghong Wang,
Daniel Calva-Cerqueira,
James R. Howe
et al.
|
S27
|
|
|
|
Increased expression of small ubiquitin-like modifier proteins in rectal adenocarcinoma patients after neoadjuvant chemoradiation
Small Ubiquitin-like Modifier (SUMO) proteins regulate DNA repair pathways by activating effectors of double-stranded DNA repair. Since SUMO proteins may influence response to radiation therapy, our o...
|
Rebecca Wiatrek,
Marjun Duldulao,
Zhenbin Chen,
Wenyan Li,
Rebecca Nelson,
Joseph Kim,
Yuan Chen,
Julio Garcia-Aguilar
et al.
|
S27
|
|
|
|
Prospective evaluation of predictive and prognostic molecular markers in colorectal carcinomas
Treatment decisions for adjuvant therapy are usually performed after surgery respecting the TNM-criteria in colorectal carcinomas (CRC). Molecular markers in the primary tumor may determine therapy re...
|
Roland S. Croner,
R. Wirtz,
H.U. Prokosch,
C. Rödel,
F. Rödel,
S. Merkel,
A. Hartmann,
O. Gefeller,
W. Hohenberger,
M. Stürzl
et al.
|
S27
|
|
|
|
Characterization of patient-derived breast cancer xenografts demonstrates molecular evolution
Directly implanting human tumors into immunodeficient mice is a popular model as it may more accurately recapitulate tumor characteristics. Prognosis is poor for breast cancer patients with minimal re...
|
Priscilla F. McAuliffe,
Ana-Maria Gonzalez-Angulo,
Argun Akcakanat,
Huiqin Chen,
Katherine S. Hale,
Kim-Anh Do,
Chandeshwar Sharma,
W. Fraser Symmans,
Gordon B. Mills,
Funda Meric-Bernstam
et al.
|
S28
|
|
|
|
Differential gene and microRNA expression in breast cancer is associated with hormone receptor status
The regulation of messenger RNA (mRNA) translation by microRNA (miRNA) has been shown to be associated with breast cancer hormone receptor expression and possibly the variable resultant clinical outco...
|
Andrew A. Wheeler,
J. Wade Davis,
Charles W. Caldwell
|
S28
|
|
|
|
A panel of four microRNAs accurately differentiates benign from malignant indeterminate thyroid lesions on fine needle aspiration
Indeterminate thyroid lesions on Fine Needle Aspiration (FNA) harbor malignancy in about 25% of cases. Hemi- or total thyroidectomy has therefore been routinely advocated for definitive diagnosis. In ...
|
Xavier M. Keutgen,
Filippo Filicori,
Michael Crowley,
Daniel Buitrago,
Theresa Scognamiglio,
Rasa Zarnegar,
Olivier Elemento,
Thomas J. Fahey
et al.
|
S28-S29
|
|
|
|
Changes in biochemical bone markers after parathyroidectomy for primary hyperparathyroidism
Assessment of bone mineral density loss associated with primary hyperparathyroidism (PHPT) is done with dual-energy x-ray absorptiometry (DEXA). DEXA is expensive and provides little information about...
|
Jovenel Cherenfant,
Nisha Chhabra,
Shalini Arora,
Tricia Moo-Young,
David J. Winchester,
Richard A. Prinz
et al.
|
S29
|
|
|
|
MicroRNA profiling of benign and malignant pheochromocytomas
Malignant pheochromocytoma is currently a diagnosis that can only be made based on the presence of clinical metastasis. The molecular basis of malignant pheochromocytoma is poorly understood and there...
|
Richard Clark Webb,
Brent Bian,
Mei He,
Ramya Krishna,
Naris Nilubol,
Karen Adams,
Karel Pacak,
Electron Kebebew
et al.
|
S29
|
|
|
|
Molecular network, pathway and functional analysis of time-dependent gene changes associated with pancreatic cancer susceptibility to oncolytic vaccinia virotherapy
Pancreatic cancer is a fatal disease associated with resistance to conventional therapies. This study aimed to determine changes in gene expression patterns associated with infection and susceptibilit...
|
Dana Haddad,
Nicholas Socci,
Nanhai G. Chen,
Qian Zhang,
Aladar A. Szalay,
Yuman Fong
et al.
|
S29-S30
|
|
|
|
BH3-only proteins have differential roles in hepatic ischemia-reperfusion injury
BH3-only protein members Bim and Bid are known mediators of apoptosis, which also have important roles in hepatic ischemia-reperfusion injury (IRI). Absence of BH3-only proteins ameliorates IRI; howev...
|
Bernard John DuBray,
Parvathi Balachandran,
Brett L. Knolhoff,
Gundumi A. Upadhya,
Jianluo Jia,
Richard S. Hotchkiss,
Thallachallour Mohanakumar,
William C. Chapman,
Christopher D. Anderson
et al.
|
S30
|
|
|
|
Detection of amyloid oligomers as a predictor of outcome in TBI patients
Traumatic brain injury (TBI) is known to be a risk factor for Alzheimer's disease, and shortly after TBI an increase in beta-amyloid monomers, beta-amyloid oligomers, and subsequent plaque formation h...
|
Joshua Gatson,
Victoria Warren,
Kareem R. Abdelfattah,
Joseph P. Minei,
Jane G. Wigginton
et al.
|
S30
|
|
|
|
Reduction of protein carbonylation in adipose tissue and improved glycemic control in patients with type 2 diabetes mellitus following Roux-en-Y gastric bypass
Insulin resistance (IR) is associated with obesity but the mechanisms controlling this relationship are not fully understood. Recent studies suggest a linkage between adipose reactive-oxygen-species (...
|
Federico J. Serrot,
Brigitte I. Frohnert,
Robert B. Dorman,
Daniel B. Leslie,
Bridget Slusarek,
David A. Bernlohr,
Sayeed Ikramuddin
et al.
|
S30-S31
|
|
| Cardiothoracic Surgery I |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Outcomes of surgical treatment for acute ascending aortic dissection in octogenarians
Outcomes for patients undergoing surgical treatment of acute ascending aortic dissection (AAAD) have improved. The objective of this study was to compare short- and long-term survival of octogenarians...
|
W. Brent Keeling,
Edward P. Chen,
Pat Kilgo,
Robert A. Guyton,
Omar M. Lattouf,
John D. Puskas,
J. David Vega,
Micheal E. Halkos,
Vinod H. Thourani
et al.
|
S32
|
|
|
|
Total aortic arch replacement under moderate hypothermic circulatory arrest with selective antegrade cerebral perfusion: Benchmark data in the endovascular era
Recent advances in thoracic endovascular repair (TEVAR) of aortic arch pathology, such as branched endografts or hybrid debranching, have expanded the application of this technology. Open total aortic...
|
Bradley G. Leshnower,
Richard J. Myung,
Edward P. Chen
|
S32
|
|
|
|
Resveratrol preserves myocardial function and perfusion to adjacent non-ischemic myocardium in a swine model of metabolic syndrome and chronic myocardial ischemia
The objective of this study was to define the impact of resveratrol on myocardium adjacent to a territory of ischemia in a swine model of metabolic syndrome and chronic myocardial ischemia.
|
Michael P. Robich,
Louis M. Chu,
Thomas A. Burgess,
Jun Feng,
Reza Nezafat,
Bianchi Cesario,
Warren J. Manning,
Roger J. Laham,
Frank W. Sellke
et al.
|
S32-S33
|
|
|
|
Doxycyline prevents borderzone contractility reduction after myocardial infarction in sheep
Contractility is reduced in the normally perfused borderzone (BZ) after myocardial infarction (MI). Reports now suggest that matrix metalloproteinase 2 (MMP2) is active not only in the interstitium bu...
|
Michael Khazalpour,
Rafael Shimkunas,
Mehrdad Soleimani,
Yifei Wu,
Anthony Baker,
Mark B. Ratcliffe
et al.
|
S33
|
|
|
|
Oxidized low-density lipoprotein transforms aortic valve interstitial cells into an osteogenic phenotype implying its role in aortic stenosis
The pathogenesis of aortic stenosis may be via an active disease process of bone formation within the aortic valve. The aortic valve interstitial cell (AVIC) is a principal cell within the aortic valv...
|
Joon Ho Lee,
Xianzhong Meng,
T. Brett Reece,
Michael J. Weyant,
Joseph C. Cleveland,
David A. Fullerton
et al.
|
S33
|
|
|
|
Silencing prolyl hydroxylase domain protein 3 stabilizes hypoxia inducible factor −1 alpha and preserves myocardial function through the activation of pro-angiogenic and anti-apoptotic pathway following myocardial injury in mice
Prolyl-hydroxylase domain proteins (PHDs) are cellular oxygen sensing molecules, that use oxygen as a substrate to hydroxylate proline residues of hypoxia-inducible factor (HIF). Three PHD isoforms (P...
|
Babatunde Oriowo,
Mahesh Thirunavukkarasu,
Sudheer Adluri,
Lijun Zhan,
Kotaro Takeda,
Guo-Hua Fong,
Juan A. Sanchez,
Nilanjana Maulik
et al.
|
S33-S34
|
|
|
|
Traditional open repair of traumatic thoracic aortic injury remains relevant in the endovascular era
The management of blunt thoracic aortic injury (BTAI) has undergone a dramatic shift over the last decade. Traditional open methods of repair have increasingly given way to endovascular stent grafting...
|
Robert M. Cannon,
Jaimin R. Trivedi,
Jennifer N. Bland,
Amit Dwivedi,
Charles B. Ross,
Mark S. Slaughter,
J.D. Richardson,
Matthew L. Williams
et al.
|
S34
|
|
|
|
Cardiac catheterization within three days of aortic surgery is not associated with postoperative acute kidney injury
Cardiac catheterization shortly before coronary artery bypass grafting (CABG) or valve surgery increases the risk of postoperative acute kidney injury (AKI). The optimum timing of catheterization prio...
|
Nicholas D. Andersen,
Judson B. Williams,
Emil L. Fosbol,
Asad A. Shah,
Syamal D. Bhattacharya,
Rajendra H. Mehta,
G. Chad Hughes
et al.
|
S34-S35
|
|
|
|
Preservation of the NADPH redox system is not responsible for the protective effects of ischemic preconditioning
Cardiac ischemia-reperfusion (IR) increases mitochondrial reactive oxygen species (ROS) production. Ischemic preconditioning (IPC) decreases ROS production. The mechanism of IPC may involve changing t...
|
Ricardo Quarrie,
Daniel S. Lee,
Brandon Cramer,
Warren Erdahl,
Douglas R. Pfeiffer,
Jay L. Zweier,
Juan A. Crestanello
et al.
|
S35
|
|
