Journal of the American College of Surgeons
Volume 211, Issue 3 , Pages 384-390 , September 2010

Consequences of Adrenal Venous Sampling in Primary Hyperaldosteronism and Predictors of Unilateral Adrenal Disease

  • Aarti Mathur, MD

      Affiliations

    • Endocrine Oncology Section, Surgery Branch, National Cancer Institute
    • ,
  • Clinton D. Kemp, MD

      Affiliations

    • Endocrine Oncology Section, Surgery Branch, National Cancer Institute
    • ,
  • Utpal Dutta, MD

      Affiliations

    • Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institutes of Child Health and Human Development (NICHD)
    • ,
  • Smita Baid, MD

      Affiliations

    • Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institutes of Child Health and Human Development (NICHD)
    • ,
  • Alejandro Ayala, MD

      Affiliations

    • Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institutes of Child Health and Human Development (NICHD)
    • ,
  • Richard E. Chang, MD

      Affiliations

    • Department of Diagnostic Radiology, Warren F Magnuson Clinical Center
    • ,
  • Seth M. Steinberg, PhD

      Affiliations

    • Biostatistics and Data Management Section, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute
    • ,
  • Vasilios Papademetriou, MD

      Affiliations

    • Veterans Administration and Georgetown University, Washington DC
    • ,
  • Eileen Lange, RN, CCRP

      Affiliations

    • Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institutes of Child Health and Human Development (NICHD)
    • ,
  • Steven K. Libutti, MD, FACS

      Affiliations

    • Department of Surgery, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY
    • ,
  • James F. Pingpank, MD, FACS

      Affiliations

    • Division of Surgical Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA
    • ,
  • H. Richard Alexander, MD, FACS

      Affiliations

    • Department of Surgery, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD
    • ,
  • Giao Q. Phan, MD

      Affiliations

    • Endocrine Oncology Section, Surgery Branch, National Cancer Institute
    • ,
  • Marybeth Hughes, MD, FACS

      Affiliations

    • Endocrine Oncology Section, Surgery Branch, National Cancer Institute
    • ,
  • W. Marston Linehan, MD

      Affiliations

    • Urologic Oncology Branch, National Cancer Institute
    • ,
  • Peter A. Pinto, MD

      Affiliations

    • Urologic Oncology Branch, National Cancer Institute
    • ,
  • Constantine A. Stratakis, MD, D(Med)Sci

      Affiliations

    • Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institutes of Child Health and Human Development (NICHD)
    • ,
  • Electron Kebebew, MD, FACS

      Affiliations

    • Endocrine Oncology Section, Surgery Branch, National Cancer Institute
    • Corresponding Author InformationCorrespondence address: Electron Kebebew, MD, FACS, National Cancer Institute Surgery Branch CRC, Room 4-5952, 10 Center Dr, MSC 1201, Bethesda, MD 20892-1201

Received 5 March 2010 ,Revised 4 May 2010 ,Accepted 11 May 2010.

References 

  1. McKenzie TJ, Lillegard JB, Young WF, Thompson GB. Aldosteronomas—state of the art. Surg Clin North Am. 2009;89:1241–1253
  2. Mulatero P, Stowasser M, Loh KC, et al. Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents. J Clin Endocrinol Metab. 2004;89:1045–1050
  3. Young WF. Minireview: primary aldosteronism-changing concepts in diagnosis and treatment. Endocrinology. 2003;144:2208–2213
  4. Young WF, Stanson AW, Thompson GB, et al. Role for adrenal venous sampling in primary aldosteronism. Surgery. 2004;136:1227–1235
  5. Milliez P, Girerd X, Plouin PF, et al. Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism. J Am Coll Cardiol. 2005;45:1243–1248
  6. Funder JW, Carey RM, Fardella C, et al. Case detection, diagnosis, and treatment of patients with primary aldosteronism: an Endocrine Society clinical practice guideline. Endocrinol Metab. 2008;93:3266–3281
  7. Melby JC, Spark RF, Dale SL, et al. Diagnosis and localization of aldosterone-producing adenomas by adrenal-vein catheterization. N Engl J Med. 1967;277:1050–1056
  8. Stewart PM, Allolio B. Adrenal vein sampling for primary aldosteronism: time for a reality check. Clin Endocrinol. 2010;72:146–148
  9. Mulatero P, Bertello C, Sukor N, et al. Impact of different diagnostic criteria during adrenal vein sampling on reproducibility of subtype diagnosis in patients with primary aldosteronism. Hypertension. 2010;55:667–673
  10. Magill SB, Raff H, Shaker JL, et al. Comparison of adrenal vein sampling and computed tomography in the differentiation of primary aldosteronism. J Clin Endocrinol Metab. 2001;86:1066–1071
  11. Phillips JL, Walther MM, Pezzullo JC, et al. Predictive value of preoperative tests in discriminating bilateral adrenal hyperplasia from an aldosterone-producing adenoma. J Clin Endocrinol Metab. 2000;85:4526–4533
  12. Kempers MJ, Lenders JW, van Outheusden L, et al. Systematic review: diagnostic procedures to differentiate unilateral from bilateral adrenal abnormality in primary aldosteronism. Ann Intern Med. 2009;151:329–337
  13. Zarnegar R, Bloom AI, Lee J, et al. Is adrenal venous sampling necessary in all patients with hyperaldosteronism before adrenalectomy?. J Vasc Interv Radiol. 2008;19:66–71
  14. Kline GA, Harvey A, Jones C, et al. Adrenal vein sampling may not be a gold-standard diagnostic test in primary aldosteronism: final diagnosis depends upon which interpretation rule is used. Int Urol Nephrol. 2008;40:1035–1043
  15. Harvey A, Kline G, Pasieka JL. Adrenal venous sampling in primary hyperaldosteronism: Comparison of radiographic with biochemical success and the clinical decision-making with “less than ideal” testing. Surgery. 2006;140:847–855
  16. Doppman JL, Gill JR. Hyperaldosteronism: Sampling the adrenal veins. Radiology. 1996;198:309–312
  17. Sawka AM, Young WF, Thompson GB, et al. Primary aldosteronism: factors associated with normalization of blood pressure after surgery. Ann Intern Med. 2001;135:258–261
  18. Zarnegar R, Young WF, Lee J, et al. The aldosteronoma resolution score (Predicting complete resolution of hypertension after adrenalectomy for aldosteronoma). Ann Surg. 2008;247:511–518

 Disclosure Information: Nothing to disclose.

 This research was supported by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research.

PII: S1072-7515(10)00343-1

doi: 10.1016/j.jamcollsurg.2010.05.006

Journal of the American College of Surgeons
Volume 211, Issue 3 , Pages 384-390 , September 2010

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