« Previous
Next »
Journal of the American College of Surgeons
Volume 210, Issue 3
, Pages 271-279
, March 2010
Low Oxygen-Affinity Hemoglobin Solution Increases Oxygenation of Partially Ischemic Tissue During Acute Anemia
References
- . Necrotizing fasciitis: current concepts and review of the literature. J Am Coll Surg. 2009;208:279–288
- Survival, hemodynamics, and tissue oxygenation after head trauma. J Am Coll Surg. 2006;202:120–130
- . Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria. J Biol Chem. 1981;256:10986–10992
- . Blood substitutes. Curr Opin Hematol. 2002;9:146–151
- . Oxygen therapeutics: can we tame haemoglobin?. Nat Rev Drug Discov. 2004;3:152–159
- . Oxygen transport agents: a new approach to red blood cell alternatives. TATM. 2004;5:498–504
- . Quantitation of rhythmic diameter changes in arterial microcirculation. Am J Physiol. 1984;246:H508–H517
- . Technical report: a new chamber technique for microvascular studies in unanaesthetized hamsters. Res Exp Med. 1980;177:125–134
- . Guide for the care and use of laboratory animals. Washington, DC: National Academy Press; 1996;
- . Role of endothelial nitric oxide in microvascular oxygen delivery and consumption. Free Radic Biol Med. 2005;39:1229–1237
- . Statistics notes: how to randomize. BMJ. 1999;319:703–704
- . Microvascular pressure and functional capillary density in extreme hemodilution with low and high plasma viscosity expanders. Am J Physiol. 2004;287:H363–H373
- . Application of the “two-slit” photometric technique to the measurement of microvascular volumetric flow rates. Microvasc Res. 1978;15:93–101
- . Microvascular measurements by video image shearing and splitting. Microvasc Res. 1973;5:309–312
- Plasma viscosity regulates capillary perfusion during extreme hemodilution in hamster skin fold model. Am J Physiol. 1998;275:H2170–H2180
- pO2 measurements by phosphorescence quenching: characteristics and applications of an automated system. Microvasc Res. 2003;65:32–38
- . Increased tissue PO2 and decreased O2 delivery and consumption after 80% exchange transfusion with polymerized hemoglobin. Am J Physiol. 2004;287:H2825–H2833
- . Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions. Am J Physiol Heart Circ Physiol. 2006;291:H2445–H2452
- . Targeted O2 delivery by low-P50 hemoglobin: a new basis for O2 therapeutics. Am J Physiol Heart Circ Physiol. 2003;285:H1411–H1419
- . Redox cycling of diaspirin crosslinked hemoglobin induces G2/M arrest and apoptosis in cultured endothelial cells. Blood. 2001;98:3315–3323
- Acellular hemoglobin-mediated oxidative stress toward endothelium: a role for ferryl iron. Am J Physiol. 1998;275:H1046–H1053
- . Heme protein radicals: formation, fate, and biological consequences. Free Radic Biol Med. 1998;24:269–279
- Resuscitation with a blood substitute causes vasoconstriction without nitric oxide scavenging in a model of arterial hemorrhage. J Am Coll Surg. 2004;199:693–701
Disclosure Information: Nothing to disclose.
This work was supported by Bioengineering Research Partnership grant R24-HL64395, Program project P01 HL071064, and grants R01-HL62354, R01-HL62318, and R01-HL76182.
PII: S1072-7515(09)01560-9
doi: 10.1016/j.jamcollsurg.2009.11.005
© 2010 American College of Surgeons. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Journal of the American College of Surgeons
Volume 210, Issue 3
, Pages 271-279
, March 2010
