Journal of the American College of Surgeons
Volume 210, Issue 2 , Pages 199-204 , February 2010

Safety and Immunogenicity Observations Pooled from Eight Clinical Trials of Recombinant Human Thrombin

  • Jeffrey L. Ballard, MD, FACS

      Affiliations

    • Vascular and Interventional Specialists of Orange County, Inc, Orange, CA
    • ,
  • Fred A. Weaver, MD, FACS

      Affiliations

    • USC CardioVascular Thoracic Institute, USC University Hospital, Keck School of Medicine, University of Southern California, Los Angeles, CA
    • ,
  • Neil K. Singla, MD

      Affiliations

    • Lotus Clinical Research, Huntington Memorial Hospital, Pasadena, CA
    • ,
  • William C. Chapman, MD, FACS

      Affiliations

    • Department of Surgery, Washington University in St Louis School of Medicine, St Louis MO
    • ,
  • W. Allan Alexander, MD

      Affiliations

    • ZymoGenetics, Inc, Seattle, WA
    • Corresponding Author InformationCorrespondence address: W Allan Alexander, MD, ZymoGenetics, Inc, 1201 Eastlake Ave E, Seattle, WA 98102

Received 24 July 2009 ,Accepted 29 September 2009.

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 The clinical trials were supported in full by ZymoGenetics.

 Disclosure Information: Dr Alexander is a salaried employee and holds an ownership interest in ZymoGenetics, Inc, and Dr Weaver is a speaker who has received honoraria from ZymoGenetics, Inc. The other authors have nothing to disclose.

 ClinicalTrials.gov: NCT00491608, NCT00371215, NCT00245336.

PII: S1072-7515(09)01458-6

doi: 10.1016/j.jamcollsurg.2009.09.042

Journal of the American College of Surgeons
Volume 210, Issue 2 , Pages 199-204 , February 2010

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