C-Reactive Protein 1059G>CGenetic Polymorphism Influences Serum C-Reactive Protein Levels after Esophagectomy in Patients with Thoracic Esophageal Cancer
Received 9 January 2009; received in revised form 15 June 2009; accepted 17 June 2009. published online 10 August 2009.
Background
Little is known about how C-reactive protein (CRP) genetic polymorphisms influence the rise in serum CRP levels seen after surgery. The purpose of this study was to assess the association between CRP polymorphisms and acute-phase serum CRP levels after esophagectomy for thoracic esophageal cancer.
Study Design
We enrolled 110 patients who underwent curative esophagectomy without neoadjuvant treatment between 2003 and 2008. Using peripheral blood samples collected from the patients, polymorphisms for CRP, tumor necrosis factor, interferon-γ, tumor growth factor-β1, interleukin (IL)-1β, IL-1 receptor antagonist, IL-2, IL-4, IL-6, IL-6 receptor, IL-10, and IL-12β were all investigated to determine which, if any, affect postoperative serum CRP levels and clinical outcomes.
Results
Although preoperative serum CRP levels did not differ, 12 hours after esophagectomy, serum CRP levels were significantly higher in patients carrying the CRP 1059G/G genotype than in those with the 1059G/C genotype (111 ± 35 mg/L versus 78 ± 17 mg/L; p = 0.0266), and after 36 hours CRP levels remained higher in those with the 1059G/G genotype (217 ± 63 mg/L versus 140 ± 51 mg/L; p = 0.0020). Logistic regression models revealed that patients carrying the CRP 1059G/G genotype had a significantly higher likelihood of a postesophagectomy increase in serum CRP, although the CRP 1059G>C genetic polymorphism had no effect on clinical outcomes. None of the other cytokine genetic polymorphisms influenced postoperative serum CRP levels.
Conclusions
Our findings suggest that the CRP 1059G>C genetic polymorphism is 1 determinant of serum CRP levels after major surgery.
aDepartment of Surgery, Akita University School of Medicine, Akita, Japan
bDepartment of Pharmacy, Akita University Hospital, Akita, Japan
Correspondence address: Satoru Motoyama, MD, Department of Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita, Japan, 010-8543
Disclosure Information: Nothing to disclose.
This work was supported, in part, by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Science, Sports, and Technology of Japan.
ABSTRACT