Journal of the American College of Surgeons
Volume 208, Issue 2 , Pages 218-228 , February 2009

Operations for Intrahepatic Cholangiocarcinoma: Single-Institution Experience of 158 Patients

  • Hauke Lang, MA, MD, FACS

      Affiliations

    • Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany
    • Corresponding Author InformationCorrespondence address: Hauke Lang, MA, MD, FACS, Department of General and Abdominal Surgery, Johannes Gutenberg University Hospital Mainz, Langenbeckstraße 1, 55131 Mainz, Germany
    • ,
  • Georgios C. Sotiropoulos, MD

      Affiliations

    • Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany
    • ,
  • George Sgourakis, MD

      Affiliations

    • Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany
    • ,
  • Klaus J. Schmitz, MD

      Affiliations

    • Institute of Pathology and Neuropathology, University Hospital Essen, Essen, Germany
    • ,
  • Andreas Paul, MD, FRCS

      Affiliations

    • Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany
    • ,
  • Philip Hilgard, MD

      Affiliations

    • Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany
    • ,
  • Thomas Zöpf, MD

      Affiliations

    • Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany
    • ,
  • Tanja Trarbach, MD

      Affiliations

    • Department of Medical Oncology, University Hospital Essen, Essen, Germany
    • ,
  • Massimo Malagó, MD

      Affiliations

    • Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany
    • ,
  • Hideo A. Baba, MD

      Affiliations

    • Institute of Pathology and Neuropathology, University Hospital Essen, Essen, Germany
    • ,
  • Christoph E. Broelsch, MD, FACS

      Affiliations

    • Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany

Received 28 July 2008 ,Revised 5 October 2008 ,Accepted 8 October 2008.

References 

  1. De Groen PC, Gores GJ, LaRusso NF, et al. Biliary tract cancers. N Engl J Med. 1999;341:1368–1378
  2. Patel T. Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States. Hepatology. 2001;33:1353–1357
  3. Taylor-Robinson SD, Toledano MB, Arora S, et al. Increase in mortality rates from intrahepatic cholangiocarcinoma in England and Wales 1968−1998. Gut. 2001;48:816–820
  4. Cherqui D, Tantawi B, Alon R, et al. Intrahepatic cholangiocarcinoma (Results of aggressive surgical management). Arch Surg. 1995;130:1073–1078
  5. Pichlmayr R, Lamesch P, Weimann A, et al. Surgical treatment of cholangiocellular carcinoma. World J Surg. 1995;19:83–88
  6. Berdah SV, Delpero JR, Garcia S, et al. A western surgical experience of peripheral cholangiocarcinoma. Br J Surg. 1996;83:1517–1521
  7. Casavilla FA, Marsh JW, Iwatsuki S, et al. Hepatic resection and transplantation for peripheral cholangiocarcinoma. J Am Coll Surg. 1997;185:429–436
  8. Chou FF, Sheen-Chen SM, Chen YS, et al. Surgical treatment of cholangiocarcinoma. Hepatogastroenterology. 1997;44:760–765
  9. Chu KM, Lai EC, Al-Hadeedi S, et al. Intrahepatic cholangiocarcinoma. World J Surg. 1997;21:301–306
  10. Harrison LE, Fong Y, Klimstra DS, et al. Surgical treatment of 32 patients with peripheral intrahepatic cholangiocarcinoma. Br J Surg. 1998;85:1068–1070
  11. Lieser MJ, Barry MK, Rowland C, et al. Surgical management of intrahepatic cholangiocarcinoma: a 31-year experience. J Hepatobiliary Pancreat Surg. 1998;5:41–47
  12. Madariaga JR, Iwatsuki S, Todo S, et al. Liver resection for hilar and peripheral cholangiocarcinomas: a study of 62 cases. Ann Surg. 1998;227:70–79
  13. Roayaie S, Guarrera JV, Ye MQ, et al. Aggressive surgical treatment of intrahepatic cholangiocarcinoma: predictors of outcomes. J Am Coll Surg. 1998;187:365–372
  14. Sasaki A, Aramaki M, Kawano K, et al. Intrahepatic peripheral cholangiocarcinoma: mode of spread and choice of surgical treatment. Br J Surg. 1998;85:1206–1209
  15. Yamamoto M, Takasaki K, Yoshikawa T. Extended resection for intrahepatic cholangiocarcinoma in Japan. J Hepatobiliary Pancreat Surg. 1999;6:117–121
  16. Inoue K, Makuuchi M, Takayama T, et al. The separate-lesion type cholangiocarcinoma. Surgery. 2000;127:498–505
  17. Weimann A, Varnholt H, Schlitt HJ, et al. Retrospective analysis of prognostic factors after liver resection and transplantation for cholangiocarcinoma. Br J Surg. 2000;87:1182–1188
  18. Itamoto T, Asahara T, Katayama K, et al. Hepatic resection for intrahepatic cholangiocarcinoma: relation to gross tumor morphology. Hepatogastroenterology. 2001;48:1129–1133
  19. Weber SM, Jarnagin WR, Klimstra D, et al. Intrahepatic cholangiocarcinoma: resectability, recurrence patterns, and outcomes. J Am Coll Surg. 2001;193:384–391
  20. Hanazaki K, Kajikawa S, Shimozawa N, et al. Prognostic factors of intrahepatic cholangiocarcinoma after hepatic resection: univariate and multivariate analysis. Hepatogastroenterology. 2002;49:311–316
  21. Kawarada Y, Yamagiwa K, Das BC. Analysis of the relationships between clinicopathologic factors and survival time in intrahepatic cholangiocarcinoma. Am J Surg. 2002;183:679–685
  22. Ohtsuka M, Ito H, Kimura F, et al. Results of surgical treatment for intrahepatic cholangiocarcinoma and clinicopathological factors influencing the survival. Br J Surg. 2002;89:1525–1537
  23. Morimoto Y, Tanaka Y, Ito T, et al. Long-term survival and prognostic factors in the surgical treatment for intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg. 2003;10:432–440
  24. Ohtsuka M, Ito H, Kimura F, et al. Extended hepatic resection and outcomes in intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg. 2003;10:259–264
  25. Lang H, Sotiropoulos GC, Dömland M, et al. Extended hepatectomy for intrahepatic cholangiocellular carcinoma (ICC)—when is it worthwhile? (Single center experience with 27 resections in 50 patients over a 5-years-period). Ann Surg. 2005;241:134–143
  26. Nakagawa T, Kamiyama T, Kurauchi N, et al. Number of lymph node metastases is a significant prognostic factor in intrahepatic cholangiocarcinoma. World J Surg. 2005;29:728–733
  27. Puhalla H, Schuell B, Pokorny H, et al. Treatment and outcome of intrahepatic cholangiocellular carcinoma. Am J Surg. 2005;189:173–177
  28. Lang H, Sotiropoulos GC, Brokalaki E, et al. Surgical therapy of intrahepatic cholangiocellular carcinoma. Chirurg. 2006;77:53–60
  29. Miwa S, Miyagawa S, Kobayashi A, et al. Predictive factors for intrahepatic cholangiocarcinoma recurrence in the liver following surgery. J Gastroenterol. 2006;41:893–900
  30. DeOliveira ML, Cunningham SC, Cameron JL, et al. Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution. Ann Surg. 2007;245:755–762
  31. Shimada K, Sano T, Sakamoto Y, et al. Clinical impact of the surgical margin status in hepatectomy for solitary mass-forming type intrahepatic cholangiocarcinoma without lymph node metastases. J Surg Oncol. 2007;96:160–165
  32. Sobin LH, Wittekind CH. TNM classification of malignant tumours. 6th ed.. West Sussex: John Wiley & Sons Ltd; 2002;
  33. D'Angelica M, Fong Y, Weber S, et al. The role of staging laparoscopy in hepatobiliary malignancy: prospective analysis of 40 cases. Ann Surg Oncol. 2003;10:183–189
  34. Barbot DJ, Marks JH, Feld RI, et al. Improving staging of liver tumors using laparoscopic intraoperative ultrasound. J Surg Oncol. 1997;64:63–67
  35. Lang H, Radtke A, Hindennach M, et al. Impact of virtual tumor resection and computer-assisted risk analysis on operation planning and intraoperative strategy in major hepatic resection. Arch Surg. 2005;140:629–638
  36. Riechelmann RP, Townsley CA, Chin SN, et al. Expanded phase II trial of gemcitabine and capecitabine for advanced biliary cancer. Cancer. 2007;110:1307–1312
  37. Iyer RV, Gibbs J, Kuvshinoff B, et al. A phase II study of gemcitabine and capecitabine in advanced cholangiocarcinoma and carcinoma of the gallbladder: a single-institution prospective study. Ann Surg Oncol. 2007;14:3202–3209
  38. Kim ST, Park JO, Lee J, et al. A phase II study of gemcitabine and cisplatin in advanced biliary tract cancer. Cancer. 2006;106:1339–1346
  39. Meyerhardt JA, Zhu AX, Stuart K, et al. Phase-II study of gemcitabine and cisplatin in patients with metastatic biliary and gallbladder cancer. Dig Dis Sci. 2008;53:564–570
  40. Shimada M, Yamashita Y, Aishima S, et al. Value of lymph node dissection during resection of intrahepatic cholangiocarcinoma. Br J Surg. 2001;88:1463–1466
  41. Konstadoulakis MM, Roayaie S, Gomatos IP, et al. Fifteen-year, single-center experience with the surgical management of intrahepatic cholangiocarcinoma: operative results and long-term outcome. Surgery. 2008;143:366–374
  42. Seo S, Hatano E, Higashi T, et al. Fluorine-18 fluorodeoxyglucose positron emission tomography predicts lymph node metastasis, P-glycoprotein expression, and recurrence after resection in mass-forming intrahepatic cholangiocarcinoma. Surgery. 2008;143:769–777
  43. Tsuji T, Hiraoka T, Kanemitsu K, et al. Lymphatic spreading pattern of intrahepatic cholangiocarcinoma. Surgery. 2001;129:401–407
  44. Shirabe K, Shimada M, Harimoto N, et al. Intrahepatic cholangiocarcinoma: its mode of spreading and therapeutic modalities. Surgery. 2002;131(Suppl):S159–S164
  45. Sotiropoulos GC, Lang H, Broelsch CE. Surgical management of recurrent intrahepatic cholangiocellular carcinoma after liver resection. Surgery. 2005;137:669–670
  46. Yamamoto M, Ariizumi S. Intrahepatic recurrence after surgery in patients with intrahepatic cholangiocarcinoma. J Gastroenterol. 2006;41:925–926

 Disclosure Information: Nothing to disclose.

PII: S1072-7515(08)01531-7

doi: 10.1016/j.jamcollsurg.2008.10.017

Journal of the American College of Surgeons
Volume 208, Issue 2 , Pages 218-228 , February 2009

Article Tools

* Image Usage & Resolution