Operations for Intrahepatic Cholangiocarcinoma: Single-Institution Experience of 158 Patients
Received 28 July 2008; received in revised form 5 October 2008; accepted 8 October 2008.
Background
Intrahepatic cholangiocarcinoma (ICC) is a rare primary liver malignancy. Until now, outcomes and prognostic factors after liver resection for these tumors have not been well-documented.
Study Design
Between April 1998 and December 2006, a total of 158 patients underwent surgical exploration in our institution for intended liver resection of ICC. Prospectively collected data of patients undergoing liver resection (n = 83) were analyzed with regard to preoperative findings, operative details, perioperative morbidity and mortality, pathologic findings, outcomes measured by tumor recurrence and survival, and prognostic factors for outcomes.
Results
Tumors were solitary in 47 patients. R0 resections were achieved in 53 patients. Vascular infiltration and lymph node metastasis were detected in 41% and 34%, respectively. After resection, the calculated 1-, 3-, and 5-year-survival rates were 71%, 38%, and 21%, respectively, with corresponding rates of 83%, 50%, and 30% in R0 resections. For 14 variables evaluated, only gender (p = 0.008), Union Internationale Contre le Cancer stage (p = 0.014), and R classification (p = 0.001) showed predictive value in the multivariate Cox proportional hazard regression.
Conclusions
Results presented outline that an R0 resection leads to substantially prolonged survival in ICC and represents the considerable input of the surgeon to the outcomes of these patients. Union Internationale Contre le Cancer stage remains an important factor.
aDepartment of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany
bInstitute of Pathology and Neuropathology, University Hospital Essen, Essen, Germany
cDepartment of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany
dDepartment of Medical Oncology, University Hospital Essen, Essen, Germany
Correspondence address: Hauke Lang, MA, MD, FACS, Department of General and Abdominal Surgery, Johannes Gutenberg University Hospital Mainz, Langenbeckstraße 1, 55131 Mainz, Germany
ABSTRACT