Nationwide Volume and Mortality after Elective Surgery in Cirrhotic Patients
Presented at the 3rd Annual Academic Surgical Congress, Huntington Beach, CA, February 2008, and Massachusetts Chapter of the American College of Surgeons, Boston, MA, December 2007.
Received 31 May 2008; received in revised form 10 September 2008; accepted 10 September 2008. published online 31 October 2008.
Background
The outcomes after elective surgery in patients with cirrhosis have not been well studied.
Study Design
We used the Nationwide Inpatient Sample (NIS) to identify all patients undergoing elective surgery for four index operations (cholecystectomy, colectomy, abdominal aortic aneurysm repair, and coronary artery bypass grafting) from 1998 to 2005. Elixhauser comorbidity measures were used to characterize patients' disease burden. Three distinct groups were created based on severity of liver disease: patients without cirrhosis (NON-CIRR), those with cirrhosis (CIRR), and patients with cirrhosis complicated by portal hypertension (PHTN). In-hospital mortality was the primary endpoint.
Results
There were 22,569 patients with cirrhosis (of whom 4,214 had PHTN) who underwent 1 of the 4 index operations compared with approximately 2.8 million patients without cirrhosis having these operations. Patients with CIRR or PHTN were more likely to be women (49.5% versus 44.0%, p < 0.0001) and were less likely to be treated in a large hospital (62.8% versus 67.6%, p < 0.0001) than NON-CIRR patients. Length of hospital stay and total charges per hospitalization increased with severity of liver disease for all operations (p < 0.001, respectively). Adjusted mortality rates increased with increasing liver disease for each operation (cholecystectomy: CIRR hazard ratio [HR] 3.4, 95% CI 2.3 to 5.0; PHTN HR 12.3, 95% CI 7.6 to 19.9; colectomy: CIRR HR 3.7, 95% CI 2.6 to 5.2; PHTN HR 14.3, 95% CI 9.7 to 21.0; coronary artery bypass grafting: CIRR HR 8.0, 95% CI 5.0 to 13.0, PHTN HR 22.7, 95% CI 10.0 to 53.8; abdominal aortic aneurysm: CIRR HR 5.0, 95% CI 2.6 to 9.8, PHTN HR 7.8, 95% CI 2.3 to 26.5).
Conclusions
In-hospital mortality, length of stay, and total hospital charges are significantly higher after elective surgery in cirrhotic patients, even in the absence of portal hypertension. Careful decision-making about surgery in these patients is critical as the nationwide increase in hepatitis C and cirrhosis continues.
aDepartment of Surgery, Surgical Outcomes Analysis & Research, University of Massachusetts Medical School, Worcester, MA
bDepartment of Surgery, Surgical Outcomes Analysis & Research, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Correspondence address: Shimul A Shah, MD, Division of Organ Transplantation, Surgical Outcomes Analysis & Research, Department of Surgery, University of Massachusetts Medical School, 55 Lake Ave North, S6–432, Worcester, MA 01655
Disclosure Information: Nothing to disclose.
Supported by the American Society of Transplant Surgeons Faculty Development Award and Worcester Foundation for Biomedical Research (SAS).
ABSTRACT