Journal of the American College of Surgeons
Volume 205, Issue 4 , Pages 527-533 , October 2007

Angiotensin II Type 2 Receptor Provides an Endogenous Brake During Inflammation-Induced Microvascular Fluid Leak

Received 19 July 2007 ,Accepted 20 July 2007.

References 

  1. Chung O, Stoll M, Unger T. Physiologic and pharmacologic implications of AT1 versus AT2 receptors. Blood Press Suppl. 1996;2:47–52
  2. Chiu AT, Smith RD, Timmermans PB. Defining angiotensin receptor subtypes. In:  Saavedra JM,  Timmermans PB editor. Angiotensin receptors. New York: Plenum Press; 1994;p. 49–65
  3. Timmermans PB, Wong PC, Chiu AT, Herblin WF. Nonpeptide angiotensin II receptor antagonists. Trends Pharmacol Sci. 1991;12:55–62
  4. Nora EH, Munzenmaier DH, Hansen-Smith FM, et al. Localization of the AngII type 2 receptor in the microcirculation of skeletal muscles. Am J Physiol. 1998;275:H1394–H1403
  5. Patel JM, Yarid FR, Block ER, Raizada MK. Angiotensin receptors in pulmonary arterial and aortic endothelial cells. Am J Physiol. 1989;256:C987–C983
  6. Hilton JG, Marullo DS. Trauma induced increases in plasma vasopressin and angiotensin II. Life Sci. 1987;41:2195–2200
  7. Michel CC, Curry FE. Microvascular permeability. Physiol Rev. 1999;79:703–756
  8. Reilly PM, Bulkey GB. Vasoactive mediators and splanchnic perfusion. Crit Care Med. 1993;21(2 suppl):S55–S68
  9. Suzuki Y, Ruiz-Ortega M, Lorenzo O, et al. Inflammation and angiotensin II. Int J Biochem Cell Biol. 2003;5:881–900
  10. Victorino GP, Newton CR, Curran B. Dose dependent actions and temporal effects of angiotensin II on microvascular permeability. J Trauma. 2003;55:527–530
  11. Victorino GP, Newton CR, Curran B. The effect of angiotensin II on microvascular permeability. J Surg Res. 2002;104:77–81
  12. Pinheiro H, Moura D, Albino-Teixeira A, et al. A comparison of AT1 angiotensin II antagonists at pre- and postjunctional angiotensin II receptors of the rat tail artery. Naunyn Schmiedebergs Arch Pharmacol. 2002;366:537–542
  13. Newton CR, Curran B, Victorino GP. Angiotensin II type 2 receptor effect on microvacular hydraulic permeability. J Surg Res. 2004;120:83–88
  14. Victorino GP, Newton CR, Curran B. Modulation of microvascular hydraulic permeability by platelet-activating factor. J Trauma. 2002;56:379–384
  15. Curry FE, Huxley VH, Sarelius IH. Techniques in microcirculation: Measurement of permeability, pressure, and flow. In:  Linden RT editors. Cardiovascular physiology (Techniques in the life sciences). New York: Elsevier; 1983;p. 1–34
  16. Predescu D, Palade GE. Plasmalemmal vesicles represent the large pore system of continuous microvascular endothelium. Am J Physiol. 1993;265:H725–H733
  17. Catt KJ, Medelsohn FAC, Millan MA. The role of angiotensin II receptors in vascular regulation. Cardiovasc Pharmacol. 1984;4(6 Suppl):5575–5586
  18. Reddy HK, Campbell SE, Janicki JS, et al. Coronary microvascular fluid flux and permeability: influence of angiotensin II, aldosterone, and acute arterial hypertension. J Lab Clin Med. 1993;121:510–521
  19. Robertson AL, Khairallah PA. Effect of angiotensin II and some analogs on vascular permeability in the rabbit. Circ Res. 1972;31:923–931
  20. Hernandez I, Carbonell LF, Quesada T, Fenoy FJ. Role of angiotensin II in modulating the hemodynamic effects of nitric oxide synthesis inhibition. Am J Physiol. 1999;177:R104–R111
  21. Hulthen UL, Cao Z, Rumble JR, et al. Vascular hypertrophy and albumin permeability in a rat model combining hypertension and diabetes mellitus (Effects of calcium antagonism, angiotensin converting enzyme inhibition, and angiotensin II-AT1-receptor blockade). Am J Hypertens. 1996;9:895–901
  22. Fantone JC, Schrier D, Weingarten B. Inhibition of vascular permeability changes in rats by captopril. J Clin Invest. 1982;69:1207–1211
  23. Ramirez R, Chong T, Curran B, et al. Angiotensin II type 2 receptor decreases ischemia reperfusion induced fluid leak. J Surg Res. 2007;138:175–180
  24. Kifor I, Dzau VJ. Endothelial renin-angiotensin pathway: Evidence for intracellular synthesis and secretion of angiotensin. Circ Res. 1987;60:422–428
  25. Matrougui K, Loufrani L, Heymes C, et al. Activation of AT(2) receptors by endogenous angiotensin II is involved in flow-induced dilation in rat resistance arteries. J Hypertension. 1999;12:659–665
  26. Bader M, Peters J, Baltatu O, et al. Tissue rennin-angiotensin systems: new insights from experimental animal models in hypertension research. J Mol Med. 2001;79:76–102
  27. Muller DN, Bohlender J, Hilgers K, et al. Vascular angiotensin-converting enzyme expression regulates local angiotensin II. Hypertension. 1997;29:98–104
  28. Stahl GL, Craft DV, Lento PH, Lefer AM. Detection of platelet-activating factor during traumatic shock. Circ Shock. 1988;26:237–244
  29. Akiyoshi K, Akimitsu T, Hara M, et al. AT1 receptor blockade prevents microvascular dysfunction induced by ischemia/reperfusion injury. J Atheroscler Thromb. 2006;13:231–239
  30. Lefkowitz RJ, Shenoy SK. Transduction of receptor signals by beta-arrestins. Science. 2005;308:512–517
  31. Anderson K, Murahashi T, Dostal D, Peach M. Morphological and biochemical analysis of angiotensin II internalization in cultured rat aortic smooth muscle cells. Am J Physiol. 1993;264:C179–C188
  32. Griendling K, Delafontaine P, Rittenhouse S, et al. Correlation of receptor sequestration with sustained diacylglycerol accumulation in angiotensin II stimulated vascular smooth muscle cells. J Biol Chem. 1987;262:14555–14562

 Competing Interests Declared: None.

 Won first place Basic Laboratory Science Award from the Residents Trauma Paper Competition, March 2007.

PII: S1072-7515(07)01339-7

doi: 10.1016/j.jamcollsurg.2007.07.026

Journal of the American College of Surgeons
Volume 205, Issue 4 , Pages 527-533 , October 2007

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