Journal of the American College of Surgeons
Volume 205, Issue 4, Supplement , Pages S34-S37 , October 2007

Role of Surgery in Zollinger-Ellison Syndrome

  • Jeffrey A. Norton, MD, FACS

      Affiliations

    • Surgical Oncology, Department of Surgery, Stanford University, Palo Alto, California
    • Corresponding Author InformationCorrespondence address: Jeffrey A Norton, MD, FACS, Stanford University Medical Center, Department of Surgery, 300 Pasteur Drive, Room H-3591, Stanford, CA 94305-5641.
    • ,
  • Robert T. Jensen, MD

      Affiliations

    • Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Bethesda, Maryland.

Received 12 June 2007 ,Accepted 13 June 2007.

References 

  1. Zollinger RM, Ellison E. Primary peptic ulceration of the jejunum associated with islet cell tumors of the pancreas. Ann Surg. 1955;142:724–728
  2. Fox PS, Hofmann J, DeCosse JJ, Wilson SD. The influence of total gastrectomy on survival of malignant Zollinger-Ellison tumors. Ann Surg. 1974;180:558–566
  3. Wilson SD. The role of surgery in children with the Zollinger-Ellison syndrome. Surgery. 1982;92(4):682–692
  4. McCarthy DM. Report of the United States experience with cimetidine in the Zollinger-Ellison syndrome and other acid hypersecretory states. Gastroenterology. 1978;74:453–458
  5. Metz DC, Benya RV, Fishbeyn VA, et al. Prospective study of the need for long-term antisecretory therapy in patients with Zollinger-Ellison syndrome following successful curative gastrinoma resection. Aliment Pharmacol Ther. 1993;7(3):247–257
  6. Brennan MF, Jensen RT, Wesley RA, et al. The role of surgery in patients with Zollinger-Ellison syndrome managed medically. Ann Surg. 1982;196:239–245
  7. Oberhelman HA, Nelsen TS, Johnson AN, Dragstetdt LR. Ulcerogenic tumors of the duodenum. Ann Surg. 1961;153:214–227
  8. Norton JA, Doppman JL, Collen MJ, et al. Prospective study of gastrinoma localization and resection in patients with Zollinger-Ellison syndrome. Ann Surg. 1986;204(4):468–479
  9. Norton JA, Cromack DT, Shawker TH, et al. Intraoperative ultrasonographic localization of islet cell tumors (A prospective comparison to palpation). Ann Surg. 1988;207(2):160–168
  10. Thompson NW, Vinik AI, Eckhauser FE. Microgastrinomas of the duodenum (A cause of failed operations for the Zollinger-Ellison syndrome). Ann Surg. 1989;209(4):396–404
  11. Frucht H, Norton JA, London JF, et al. Detection of duodenal gastrinomas by operative endoscopic transillumination (A prospective study). Gastroenterology. 1990;99(6):1622–1627
  12. Sugg SL, Norton JA, Fraker DL, et al. A prospective study of intraoperative methods to diagnose and resect duodenal gastrinomas. Ann Surg. 1993;218(2):138–144
  13. Norton JA, Fraker DL, Alexander HR. Surgery increases survival in patients with gastrinoma. Ann Surg. 2006;244:410–419
  14. Norton JA. Intraoperative methods to stage and localize pancreatic and duodenal tumors. Ann Oncol. 1999;10(Suppl 4):182–184
  15. Pipeleers-Marichal M, Somers G, Willems G, et al. Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 and the Zollinger-Ellison syndrome. N Engl J Med. 1990;322(11):723–727
  16. Thompson NW. Current concepts in the surgical management of multiple endocrine neoplasia type 1 pancreatic-duodenal disease (Results in the treatment of 40 patients with Zollinger-Ellison syndrome, hypoglycaemia, or both). J Intern Med. 1998;243(6):495–500
  17. Doherty GM, Thompson NW. Multiple endocrine neoplasia type 1: duodenopancreatic tumours. J Intern Med. 2003;253(6):590–598
  18. Westreich R, Brower S, Lawson W. Primary lymph node malignant gastrinoma with metastasis to Virchow’s node: a case report. Otolaryngol Head Neck Surg. 2004;131(6):1027–1028
  19. Odelowo OO, Nidiry JJ, Zulu SH. Primary lymph node gastrinoma: a case report. J Natl Med Assoc. 2003;95(2):168–171
  20. Norton JA, Alexander HR, Fraker DL, et al. Possible primary lymph node gastrinoma: occurrence, natural history, and predictive factors: a prospective study. Ann Surg. 2003;237(5):650–657discussion 657–659
  21. Thompson NW, Pasieka J, Fukuuchi A. Duodenal gastrinomas, duodenotomy, and duodenal exploration in the surgical management of Zollinger-Ellison syndrome. World J Surg. 1993;17(4):455–462
  22. Norton JA, Jensen RT. Resolved and unresolved controversies in the surgical management of patients with Zollinger-Ellison syndrome. Ann Surg. 2004;240(5):757–773
  23. Gibril F, Jensen RT. Advances in evaluation and management of gastrinoma in patients with Zollinger-Ellison syndrome. Curr Gastroenterol Rep. 2005;7(2):114–121
  24. Gibril F, Jensen RT. Comparative analysis of diagnostic techniques for localization of gastrointestinal neuroendocrine tumors. Yale J Biol Med. 1997;70(5–6):509–522
  25. Norton JA, Fraker DL, Alexander HR, et al. Surgery to cure the Zollinger-Ellison syndrome. N Engl J Med. 1999;341(9):635–644
  26. Fraker DL, Norton JA, Alexander HR, et al. Surgery in Zollinger-Ellison syndrome alters the natural history of gastrinoma. Ann Surg. 1994;220(3):320–328discussion 328–330

 Competing Interests Declared: None.This research was partially supported by the Intramural Research Program of the NIDDK and NCI, NIH.

PII: S1072-7515(07)01174-X

doi: 10.1016/j.jamcollsurg.2007.06.320

Journal of the American College of Surgeons
Volume 205, Issue 4, Supplement , Pages S34-S37 , October 2007

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