Journal of the American College of Surgeons
Volume 205, Issue 4 , Pages 541-545 , October 2007

Early Predictors of Massive Transfusion in Combat Casualties

Presented as a podium presentation at the Pacific Coast Surgical Association, Kohala Coast, HI, February 2007.

  • Martin A. Schreiber, MD, FACS

      Affiliations

    • Department of Surgery, Oregon Health and Science University, Portland, OR
    • Corresponding Author InformationCorrespondence address: Martin A Schreiber, MD, FACS, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, L611, Portland, OR 97239.
    • ,
  • Jeremy Perkins, MD

      Affiliations

    • Department of Medicine, Walter Reed Army Medical Center, Washington, DC
    • ,
  • Laszlo Kiraly, MD

      Affiliations

    • Department of Surgery, Oregon Health and Science University, Portland, OR
    • ,
  • Samantha Underwood, MS

      Affiliations

    • Department of Surgery, Oregon Health and Science University, Portland, OR
    • ,
  • Charles Wade, PhD

      Affiliations

    • United States Army Institute of Surgical Research, Fort Sam Houston, TX.
    • ,
  • John B. Holcomb, MD, FACS

      Affiliations

    • United States Army Institute of Surgical Research, Fort Sam Houston, TX.

Received 22 March 2007 ,Revised 28 April 2007 ,Accepted 8 May 2007.

References 

  1. Bellamy RF. The causes of death in conventional land warfare: implications for combat casualty care research. Mil Med. 1984;149:55–62
  2. Repine TB, Perkins JG, Kauvar DS, Blackborne L. The use of fresh whole blood in massive transfusion. J Trauma. 2006;60:S59–S69
  3. Como JJ, Dutton RP, Scalea TM, et al. Blood transfusion rates in the care of acute trauma. Transfusion. 2004;44:809–813
  4. Malone D, Kuhls D, Napolitano LM, et al. Blood transfusion in the first 24 hours is associated with systemic inflammatory response syndrome and worse outcome in trauma. Crit Care Med. 2000;28:A138
  5. Davis JW, Shackford SR, Mackersie RC, Hoyt DB. Base deficit as a guide to volume resuscitation. J Trauma. 1988;28:1464–1467
  6. Davis JW, Parks S, Kaups KL, et al. Admission base deficit predicts transfusion requirements and risk of complications. J Trauma. 1996;41:769–774
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  8. Ferrara A, MacArthur JD, Wright HK, et al. Hypothermia and acidosis worsen coagulopathy in the patient requiring massive transfusion. Am J Surg. 1990;160:515–518
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  10. Como JJ, Dutton RP, Scalea TM, et al. Blood transfusion rates in the care of acute trauma. Transfusion. 2004;44:809–813
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  12. Holcomb JB, Salinas J, McManus JM, et al. Manual vital signs reliably predict need for life-saving interventions in trauma patients. J Trauma. 2005;59:821–828
  13. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma. 2003;54:1127–1130
  14. MacLeod JBA, Lynn M, McKenney MG, et al. Early coagulopathy predicts mortality in trauma. J Trauma. 2003;55:39–44
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  16. Ho AMH, Karmakar MK, Dion PW. Are we giving enough coagulation factors during major trauma resuscitation?. Am J Surg. 2005;190:479–484
  17. DeLoughery TG. Coagulation defects in trauma patients: etiology, recognition, and therapy. Crit Care Clin. 2004;20:13–24
  18. Kearney TJ, Bentt L, Grode M, et al. Coagulopathy and catecholamines in severe head injury. J Trauma. 1992;32:608–611
  19. Keller MS, Fendya DG, Weber TR. Glasgow Coma Scale predicts coagulopathy in pediatric trauma patients. Semin Pediatr Surg. 2001;10:12–16
  20. May AK, Young JS, Butler K, et al. Coagulopathy in severe closed head injury: is empiric therapy warranted?. Am Surg. 1997;63:233–237
  21. Hess JR, Holcomb JB, Hoyt DB. Damage control resuscitation: the need for specific blood products to treat the coagulopathy of trauma. Transfusion. 2006;46:685–686
  22. Kaufmann CR, Dwyer KM, Crews J, et al. Usefulness of thrombelastography in assessment of trauma patient coagulation. J Trauma. 1997;42:716–722
  23. Schreiber MA, Differding J, Thorborg P, et al. Hypercoagulability is most prevalent early after injury and in female patients. J Trauma. 2005;58:475–481
  24. Schreiber MA. Coagulopathy in the trauma patient. Curr Opin Crit Care. 2005;11:590–597
  25. Hirshberg A, Dugas M, Banez EI, et al. Minimizing dilutional coagulopathy in exsanguinating hemorrhage: a computer simulation. J Trauma. 2003;54:454–463
  26. Gonzalez EA, Moore FA, Holcomb JB, et al. Fresh frozen plasma should be given earlier to patients requiring massive transfusion. J Trauma. 2007;62:112–119

 Competing Interests Declared: None.

PII: S1072-7515(07)00625-4

doi: 10.1016/j.jamcollsurg.2007.05.007

Journal of the American College of Surgeons
Volume 205, Issue 4 , Pages 541-545 , October 2007

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