Journal of the American College of Surgeons
Volume 205, Issue 2 , Pages 256-265, August 2007

A Phase 3, Randomized, Double-Blind Comparative Study of the Efficacy and Safety of Topical Recombinant Human Thrombin and Bovine Thrombin in Surgical Hemostasis

  • William C. Chapman, MD, FACS

      Affiliations

    • Department of Surgery, Washington University, St Louis School of Medicine, St Louis, MO
    • Corresponding Author InformationCorrespondence address: William C Chapman, MD, Washington University, Department of Surgery, Section of Transplantation, 660 South Euclid Ave, Campus Box 8109, Room 6107 Queeny Tower, St Louis, MO 63110.
    • ,
  • Neil Singla, MD

      Affiliations

    • Huntington Memorial Hospital, Pasadena, CA
    • ,
  • Yuri Genyk, MD, FACS

      Affiliations

    • USC Healthcare Consultation Center, University of Southern California, Los Angeles, CA
    • ,
  • James W. McNeil, MD, FACS

      Affiliations

    • Vascular Surgery Associates, Baton Rouge, LA
    • ,
  • Kenneth L. Renkens Jr, MD, FACS

      Affiliations

    • Indiana Spine Group, Indianapolis, IN
    • ,
  • Thomas C. Reynolds, MD, PhD

      Affiliations

    • ZymoGenetics Inc, Seattle, WA
    • ,
  • Aileen Murphy, MPH

      Affiliations

    • ZymoGenetics Inc, Seattle, WA
    • ,
  • Fred A. Weaver, MD, FACS

      Affiliations

    • USC Healthcare Consultation Center, University of Southern California and LA County Hospital, Los Angeles, CA.

Received 27 February 2007; accepted 5 March 2007. published online 25 June 2007.

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 Competing Interests Declared: Authors Murphy and Reynolds were employees of ZymoGenetics, the sponsor of the trial; during the entire study. They are no longer employees of ZymoGenetics.Funding for this trial was provided by ZymoGenetics, Inc.Trial Registration: This study is registered with ClinicalTrials.gov with the identifier NCT00245336.

PII: S1072-7515(07)00456-5

doi:10.1016/j.jamcollsurg.2007.03.020

Journal of the American College of Surgeons
Volume 205, Issue 2 , Pages 256-265, August 2007

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