Journal of the American College of Surgeons
Volume 204, Issue 2 , Pages 225-235 , February 2007

Perfluorocarbon in Microcirculation During Ischemia Reperfusion

  • Pedro Cabrales, PhD

      Affiliations

    • La Jolla Bioengineering Institute, La Jolla, CA.
    • Department of Bioengineering, University of California, San Diego, La Jolla, CA.
    • Corresponding Author InformationCorrespondence address: Pedro Cabrales, PhD, La Jolla Bioengineering Institute, 505 Coast Blvd South Suite #405, La Jolla, CA 92037.
  • ,
  • Amy G. Tsai, PhD

      Affiliations

    • La Jolla Bioengineering Institute, La Jolla, CA.
  • ,
  • Marcos Intaglietta, PhD

      Affiliations

    • Department of Bioengineering, University of California, San Diego, La Jolla, CA.

Received 5 June 2006 ,Revised 23 August 2006 ,Accepted 8 November 2006.

References 

  1. Riess JG. Oxygen carriers (“blood substitutes”)–raison d’etre, chemistry, and some physiology. Chem Rev. 2001;101:2797–2920
  2. Varani J, Hirschl RB, Dame M, Johnson K. Perfluorocarbon protects lung epithelial cells from neutrophil-mediated injury in an in vitro model of liquid ventilation therapy. Shock. 1996;6:339–344
  3. Inoue N, Ramasamy S, Fukay T, et al. Shear stress modulates expression of Cu/Zn superoxide dismutase in human aortic endothelial cells. Circ Res. 1996;79:32–37
  4. Granger DN, Benoit JN, Suzuki M, Grisham MB. Leukocyte adherence to venular endothelium during ischemia-reperfusion. Am J Physiol. 1989;257:G683–G688
  5. Schmid-Schonbein GW. Capillary plugging by granulocytes and the no-reflow phenomenon in the microcirculation. Fed Proc. 1987;46:2397–2401
  6. Menger MD, Laschke MW, Amon M, et al. Experimental models to study microcirculatory dysfunction in muscle ischemia-reperfusion and osteomyocutaneous flap transfer. Langenbecks Arch Surg. 2003;388:281–290
  7. Nolte D, Menger MD, Messmer K. Microcirculatory models of ischaemia-reperfusion in skin and striated muscle. Int J Microcirc Clin Exp. 1995;15(Suppl 1):9–16
  8. Friesenecker B, Tsai AG, Instaglietta M. Capillary perfusion during ischemia-reperfusion in subcutaneous connective tissue and skin muscle. Am J Physiol. 1994;267:H2204–H2212
  9. Cabrales P, Tsai AG, Frangos JA, et al. Oxygen delivery and consumption in the microcirculation after extreme hemodilution with perfluorocarbons. Am J Physiol. 2004;287:H320–H330
  10. Woitzik J, Weinzierl N, Schilling L. Early administration of a second-generation perfluorochemical decreases ischemic brain damage in a model of permanent middle cerebral artery occlusion in the rat. Neurol Res. 2005;27:509–515
  11. Colantuoni A, Bertuglia S, Intaglietta M. Quantitation of rhythmic diameter changes in arterial microcirculation. Am J Physiol. 1984;246:H508–H517
  12. Endrich B, Asaishi K, Götz A, Messmer K. Technical report: A new chamber technique for microvascular studies in unanaesthetized hamsters. Res Exp Med. 1980;177:125–134
  13. Cabrales P, Nacharaju P, Manjula BN, et al. Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock resuscitation using peg-albumin and hydroxyethyl starch based plasma expanders. Shock. 2005;24:66–73
  14. Tsai AG, Friesenecker B, McCarthy M, et al. Plasma viscosity regulates capillary perfusion during extreme hemodilution in hamster skin fold model. Am J Physiol. 1998;275:H2170–H2180
  15. Intaglietta M, Tompkins WR. System for the measurement of velocity of microscopic particles in liquids. IEEE Trans Biomed. 1971;18:376–377
  16. Lipowsky HH, Zweifach BW. Application of the “two-slit” photometric technique to the measurement of microvascular volumetric flow rates. Microvasc Res. 1978;15:93–101
  17. Intaglietta M, Tompkins WR. On-line measurement of microvascular dimensions by television microscopy. J Appl Physiol. 1972;32:546–551
  18. Childs EW, Udobi KF, Wood JG, et al. In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock. Shock. 2002;18:423–427
  19. Altman DG, Bland JM. Statistics notes: How to randomise. BMJ. 1999;319:703–704
  20. Bajaj AK, Cobb MA, Virmani R, et al. Limitation of myocardial reperfusion injury by intravenous perfluorochemicals (Role of neutrophil activation). Circulation. 1989;79:645–656
  21. Takahashi F, Tsai TM, Fleming PE, Ogden L. The ability of oxygenated fluorocarbon solution to minimize ischemic skeletal muscle injury. Plast Reconstr Surg. 1987;80:582–590
  22. Naito R, Yokoyama K. An improved perfluorodecalin emulsion. Prog Clin Biol Res. 1978;19:81–89
  23. Mohan C, Gennaro M, Marini C, Ascer E. Reduction of the extent of ischemic skeletal muscle necrosis by perfusion with oxygenated perfluorocarbon. Am J Surg. 1992;164:194–198
  24. Flaim SF. Pharmacokinetics and side effects of perfluorocarbon-based blood substitutes. Artif Cells Blood Substit Immobil Biotechnol. 1994;22:1043–1054
  25. Paxian M, Keller SA, Huynh TT, Clemens MG. Perflubron emulsion improves hepatic microvascular integrity and mitochondrial redox state after hemorrhagic shock. Shock. 2003;20:449–457
  26. Baker JE, Boerboom LE, Olinger GN. Age and protection of the ischemic myocardium: is alkaline cardioplegia appropriate?. Ann Thorac Surg. 1993;55:747–755
  27. Heard SO, Puyana JC. The anti-inflammatory effects of perfluorocarbons: let’s get physical. Crit Care Med. 2000;28:1241–1242

 Competing Interests Declared: None.Supported by NIH grants R01-HL76182 to AGT, R24-64395, R01-62354 and R01-62318 to MI.

PII: S1072-7515(06)01707-8

doi: 10.1016/j.jamcollsurg.2006.11.007

Journal of the American College of Surgeons
Volume 204, Issue 2 , Pages 225-235 , February 2007